Some consider erythema dyschromicum perstans which is also known as ashy dermatosis as a macular variant of lichen planus. D from the department of dermatology, vargas hospital, caracas, venezuela. Alerts and notices synopsis erythema dyschromicum perstans edp, also referred to as ashy dermatosis, is an acquired hypermelanosis of unknown etiology. Most cases reported to date are of latin american and indian patients. We have experienced two cases of edp in children aged 2 and 3, both exceptionally younger than the previously reported cases. The clinical course of childhood prepubertal may differ from that of adults. The nosologic identity of edp has been challenged repeatedly as the number of patients with concurrent edplike eruptions and lichenoid disorders has increased. In adults, erythema dyschromicum perstans is more prevalent in the latin american and asian population. Histopathologic features showed an interface dermatitis, thin lichenoid and superficial perivascular infiltrates, and dermal melanophages. Erythema dyschromicum perstans definition of erythema. Topical tarolimus provides an effective and safe alternative therapeutic option in erythema dyschromicum perstans. Meaning of erythema dyschromicum perstans medical term. Dec 12, 2006 a 25yearold man presented with a 2year history of developing a slowly progressing symmetrical eruption comprised of multiple hyperpigmented slate graycolored irregular patches predominantly involving the neck, upper torso and the proximal extremities.
Therapeutic outcome with clofazimine, dapsone, oral antibiotics, vitamins, isoniazid, choloroquin, gresiofulvin, topical corticosteroids, chemical peels, sun protection, and psychotherapy has been variable and unsatisfactory. A 35 year old latina female presented with a several year history of discoloration of her chest, upper back, and arms. A variety dermatosis cenicienta predisposing factors have been cited. Clofazimine crosses the placenta, and skin discolouration has been seen in neonates. Erythema dyschromicum perstans response to isotretinoin.
Looking for online definition of erythema dyschromicum perstans in the medical dictionary. The hyperpigmented lesions vary in size from small 1cm lesions to large plaques. Edp usually affects people between the ages of 20 to 30. Automatic update in citescore measures average citations received per document published. A diagnosis was made on the basis of clinical and histological criteria. Herein, we present the successful use of nonablative fractional photothermolysis in combination with topical tacrolimus ointment. Create a free personal account to download free article pdfs, sign up for alerts, customize your interests, and more.
Erythema dyschromicum perstans edp is an acquired, generalized dermal hypermelanosis of unknown etiology. To assess the expression of several cell adhesion and lymphocyte activation molecules in erythema dyschromicum perstans lesions, and to evaluate the effect of clofazimine therapy on the expression of these molecules. Erythema dyschromicum perstans and lichen planus jama. Variable components include erythema and papulation. Erythema dyschromicum perstans connecting repositories. Many therapeutic options are available for erythema dyschromicum perstans edp, but few have been effective, except for clofazimine. We studied 6 patients with erythema dyschromicum perstans. Erythema dyschromicum perstans also known as ashy dermatosis, and dermatosis cinecienta is an uncommon skin condition with peak age of onset being young adults, but it may also be seen in children or adults of any age. We report an 8yearold east indian boy with erythema dyschromicum perstans.
This article is within the scope of wikiproject medicine, which recommends that medicinerelated articles follow the manual of style for medicinerelated articles and that biomedical information in any article use highquality medical sources. Ashy dermatozu, eritema diskromi kum perstans, gebelik. Lam3,4 clinicalprofessorofpediatricsate universityofcalgary. Mar 18, 2020 erythema dyschromicum perstans has a slow onset and is unlikely to resolve spontaneously. Erythema dyschromicum perstans jama dermatology jama. Erythema dyschromicum perstans is uncommon dermatosis of significant cosmetic morbidity.
Erythema dyschromicum perstans and ashy dermatosis the only significant difference between erythema dyschromicum perstans and ashy dermatosis has been the presence of a palpable erythematous border measuring 12 mm in width in the early stages of the former 12,19. List of disease causes of erythema dyschromicum perstans, patient stories, diagnostic guides. Jan 24, 2008 my doctor says i have erythema dyschromicum perstans. Erythema dyschromicum perstans edp and ashy dermatosis ad are pigmentary disorders of unknown etiology. Our dermatology online original article ashy dermatosis. The ashy dermatosis ad is an idiopathic acquired bluegray macular hypermelanosis, widespread, that appears in healthy individuals. Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ashgray macular pigmentation of the skin which usually occurs from age 5 through adult life. Erythema dyschromicum perstans edp can be difficult to diagnose and.
Erythema dyschromicum perstans ashy dermatosis and. There is a strong argument for considering erythe ma dyschromicum perstans as a variant of lichen planus. Authoritative facts about the skin from dermnet new zealand. In south america, another name, erythema chronicum figuratum melanodermicum, also is used.
Erythema dyschromicum perstans edp, or ashy dermatosis, is a relatively rare condition clinically characterized by slate gray to bluebrown macules often with some degree of initial inflammation. Edp is characterized by hyperpigmented macules that are ashgrey in color and may vary in size and shape. The differential diagnosis as regards to pinta and. The term erythema dyschromicum perstans was coined by venezuelan physician marion sulzberger to highlight the word erythema because an erythematous border is observed in the early lesions and also to suggest the variety and persistence of the dyschromia. May 24, 2008 dear colleagues, i would like to present this case of erythema dyschromicum perstans to contiue our valuable discussion for the case a lady with a violaceous lesions. Erythema dyschromicum perstans also known as ashy dermatosis, and dermatosis cinecienta is a skin condition with age of onset almost always before 40 years old, characterized by skin lesions that are usually symmetrical and generalized. Affected areas include the trunk, neck, face, and upper extremities. What is the abbreviation for erythema dyschromicum perstans. Proton pump inhibitorinduced erythema dyschromicum. Clinically, the condition is characterized by slowly progressive, symmetrical gray brown to blue gray macules, sometimes with an erythematous or elevated border, which is seen most commonly over the. What is erythema dyschromicum perstans erythema dyschromicum perstans is a form of acquired dermal macular hyperpigmentation characterised by wellcircumscribed round to oval or irregular patches on the face, neck and trunk that are grey in colour. Erythema dyschromican perstans is a relatively uncommon form of lichen planus, however i do encounter it rather frequently in both my the woodlands dermatology and conroe dermatology offices. Key points rare form of necrotizing vasculitis which usually affects the skin over joints and other areas exact cause is unknown, but may be associated with various underlying disorders consists of papules andor nodules which may coalesce into plaques and are red, brown, yellow, or purple.
It is an acquired dermatosis that occurs most frequently in central and south america. Erythema dyschromicum perstans northwestern scholars. Erythema dyschromicum perstans edp, also known as ashy dermatosis and dermatosis cenicienta, is a benign, uncommon skin condition that presents with generalized ashygray colored macules on the body. Edp abbreviation stands for erythema dyschromicum perstans.
Erythema dyschromicum perstans has a slow onset and is unlikely to resolve spontaneously. Please visit the project page for details or ask questions at wikipedia talk. The condition has very rarely been reported in prepubertal indian children. Five eases have been seen and examined in caracas, venezuela.
Erythema dyschromicum perstans edp is an acquired hyperpigmentation disorder characterized by asymptomatic, polycyclic, irregularly shaped light lilacgrey patches surrounded by erythematous borders in the early inflammatory stage and subsequently greyishblue patches in the later ashy stage. Erythema dyschromicum perstans edp, or ashy derma tosis, is. Erythema dyschromicum perstans treated with narrowbandultraviolet b. Erythema dyschromicum perstans edp primarily affects latin americans but is also seen in darkerpigmented people and asians. Clinical syndrome of unknown origin characterized by a progressive bluish to ashgrey hyperpigmentation. I want to know why i have it and what is the treatment. Patients were treated with clofazimine, 100 mgd, for 3 months. Herein, we describe five cases and compare light and electron microscopic findings, direct and indirect immunofluorescence, and dopapositive melanocyte counts between normal and affected skin. Disease bioinformatics research of erythema dyschromicum perstans has been linked to erythema, pigmentation disorders, dermatologic disorders, hyperpigmentation, lichen planus. Erythema dyschromicum perstans edp is a cutaneous pigmentary disturbance originally considered to be a variant of erythema perstans. The first case to be reported in the united states is described. Erythema dyschromicum perstans in pregnancy rather s.
Erythema dyschromicum perstans edp was first described in 1957, and electron microscopic studies were reported in 1969. Gebeligin tetikledigi eritema diskromikum perstans. Erythema dyschromicum perstans is an uncommon skin condition with peak age of onset being young adults, but it may also be seen in children or adults of any. Participation is free and the site has a strict confidentiality policy.
Erythema dyschromicum perstans is a recently described dermatosis that appears to be a distinct and diagnosable entity. Publications home of jama and the specialty journals of. Erythema dyschromicum perstans is a distinctive appearing dermatosis belonging to the erythema perstans group. The discoloration started on her chest and slowly progressed to the arms. Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ashgray macular pigmentation of the skin, which usually occurs from age 5 years through.
Erythema dyschromicum perstans in early childhood md. It is a form of acquired dermal macular hyperpigmentation. Erythema dyschromicum perstans article about erythema. Herein, we report a typical case of edp observed in an africanamerican man. Two patients discontinued participation in the study. Skin biopsy samples were obtained from patients before and after 3 months of. Combination therapy with prednisone and isotretinoin in. It was not associated with any cutaneous or systemic disease. These are the options to access the full texts of the publication piel. Introduction erythema dyschromicum perstans edp is a rare. Abstract ashy dermatosis ad, lichen planus pigmentosus lpp, erythema dyschromicum perstans edp, and idiopathic eruptive macular. Cutaneous mastocytosis must be distinguished from ashy dermatitis or erythema dyschromicum perstans, nodular scabies, neurofibromatosis, juvenile english pro pts in pair. Erythema dyschromicum perstans ashy dermatosis jama. The condition was accompanied by intestinal parasitism, control of which produced remission of the active skin lesions.
The lesions are usually distributed symmetrically on both sun and nonsunexposed areas including the trunk 69. The condition is seen most commonly in women and in those with more deeply pigmented skin including latin americans and asians. Erythema dyschromicum perstans ashy dermatitis entered by. Dermis erythema dyschromicum perstans information on the. A global consensus statement on ashy dermatosis, erythema. Erythema dyschromicum perstans edp, also called ashy dermatosis, is a rare acquired and chronic dermatosis, characterized by asymptomatically and progressively hyperpigmented macules of various size on the trunk, face, and extremities. Mar 18, 2020 later, erythema dyschromicum perstans was called dermatosis ceniciento, meaning ashy dermatosis, because of its ashy bluish gray color. These changes were consistent with a diagnosis of erythema dyschromicum perstans edp. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Pdf ultrastructural pathology of erythema dyschromicum. Covering all aspects of skin disease from basic science through pathology and epidemiology to clinical practice, the text is recognized for its unparalleled coverage of diagnosis.
Erythema dyschromicum perstans showing resolution in an adult nina k. In one series of 8 patients, 7 had a good or excellent response to clofazimine administered either 100 mg every other day to patients weighing less than 40 kg or 100 mg every day to patients weighing more than 40 kg. The leading primary care society for dermatology and skin surgery. Improvement of erythema dyschromicum perstans using a. Erythema dyschromicum perstans is also called ashy dermatosis of ramirez, because of. It was originally described in latin american individuals in 1957. Erythema dyschromicum perstans edp is a disorder of pigmentation that is characterized by gray or bluebrown macules or patches in individuals with fitzpatrick skin types iiiv chang et al. The condition is characterized by grayish slatecolored macules with slightly raised, erythematous borders. Volume 21, issue 2, part 2, august 1989, pages 438442. The study of erythema dyschromicum perstans has been mentioned in research publications which can be found using our bioinformatics tool. The term erythema dyschromicum perstans is credited to marion b. It is characterized by disseminated macular lesions of an ashy gray color. Combination therapy with prednisone and isotretinoin in early.
Most of the patients i have diagnosed with erythema dyschromicum perstans are females between ages 20 and 40 but it can occur in men as well. Erythema dyschromicum perstans edp is a rare cutaneous eruption of unknown etiology that often resolves in prepubertal children but is generally thought to persist in adults. Is erythema dyschromicum perstans a variant of lichen planus that occurs primarily in darker skin. She underwent modified radical mastectomy and is now free of. However, the border can be difficult to discern in darker skinned populations 12. Diseases that approximate the clinical distribution of erythema dyschromicum perstans, such as pityriasis rosea, may result in postinflammatory hyperpigmentation. Rooks textbook of dermatology is the most comprehensive work of reference available to the dermatologist. Full length report erythema dyschromicum perstans a hitherto undescribed skin disease jacinto convit, m. This report describes the presentation, histopathologic findings, and treatment. The photos of erythema dyschromicum perstans below are not recommended for people with a weak psyche. Acd az of skin erythema dyschromicum perstans and lichen.
Pdf erythema dyschromicum perstans showing resolution in an. Cutaneous pigmentation mimicking ashy dermatosis ad erythema dyschromicum perstans edp has been described with both omeprazole and esomeprazole. It is an acquired, chronic, idiopathic hypermelanosis of longstanding evolution that is characterized by bluegray color macules that look like ash. Ashy dermatosis ad, lichen planus pigmentosus lpp, erythema dyschromicum perstans edp, and idiopathic eruptive macular pigmentation are several acquired macular hyperpigmentation disorders of.
Download fulltext pdf download fulltext pdf erythema dyschromicum perstans showing resolution in an adult article pdf available july 2015 with 400 reads. Lichen planus pigmentosus, erythema dyschromicum perstans and idiopathic eruptive macular pigmentation are the three most commonly. In our case, lichen planus and erythema dyschromicum perstans may have developed coin cidentatly. Ashy dermatosis and erythema dyschromicum perstans rooks. We present a case of edp in an adult that cleared significantly after 6 years. Erythema dyschromicum perstans altmeyers enzyklopadie. Erythema dyschromicum perstans edp is an acquired hyperpigmentation disorder characterized by asymptomatic, polycyclic, irregularly. Clinically it presents as asymptomatic, ashengrayblue macules of varying sizes, most commonly on the trunk and proximal extremities. Halasz, mdd new york, new york, and new haven, connecticut key words. Chlorothalonil exposure among banana farm workers is another possible cause of edp. Sep 01, 2003 read erythema dyschromicum perstans in prepubertal children, pediatric dermatology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. A perusal of the literature revealed but two cases, to which we add another one.
Sulzbergers comment, in discussion of another paper, is as follows. Erythema dyschromicum perstans clinical presentation. Unlimited viewing of the articlechapter pdf and any associated supplements and figures. Erythema dyschromicum perstans in prepubertal children. Erythema dyschromicum perstans ashy dermatosis d e r m l. This patient is a 35 year old saudi lady that has a grayblue ill defined discoloration on neck, face and proximal arms for 7 years. Sulzberger, who suggested it when examining convits patients in caracas. Erythema dyschromicum perstans edp also known as ashy dermatosis. Proton pump inhibitors ppis are potent inhibitors of gastric acid secretion by parietal cells in gastric mucosa. Erythema dyschromicum perstans showing resolution in an adult. The etiology of edp is unknown, but many associations have been described. Recognition of erythema dyschromicum perstans in prepubertal indian children is important for proper diagnosis and to prevent unnecessary. Casereport erythema dyschromicum perstans in an 8yearold indian child alexanderk. This condition has been described more commonly in fitzpatrick skin types iii and iv and does not appear to have an age or gender predilection.
We wish you a cure and never get sick of this disease. Erythema dyschromicum perstans showing resolution in an. Antonov, bs,a irwin braverman, md,b antonio subtil, md, mba,b,c and charles l. Edp usually appears in adults, but some isolated cases and small series have been reported in prepubertal children. The condition has very rarely been reported in prepubertal. Erythema dyschromicum perstans american osteopathic college.
Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ash. Erythema dyschromicum perstans edp is a cosmetically distressing, acquired pigmentary disorder of unknown etiology for which few successful therapies exist. Erythema dyschromicum perstans can be cosmetically distressing and socially embarrassing, especially if the lesion occurs in a visible area such as the face 1, 21. Background erythema dyschromicum perstans edp or ashy dermatosis is a peculiar, slowly progressive, macular hyperpigmentation, which leaves a permanent discoloration. Erythema dyschromicum perstans must be distinguished from postinflammatory hyperpigmentation and fixed drug eruption. Erythema dyschromicum perstans in an 8yearold indian child. It typically presents as asymptomatic, chronic, slowly progressive ashygray hyperpigmented macules on the trunk and proximal extremities. The world health organisation recommends that clofazimine is continued during pregnancy, as the symptoms of leprosy appear to worsen over this time. Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ashgray macular pigmentation of the skin. The spanish term cenicienta also means cinderella because of this folklore characters close association with ashes from sitting at home alone by. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for erythema dyschromicum perstans. Ultrastructural pathology of erythema dyschromicum perstans1 article pdf available in journal of investigative dermatology 522. Jul 31, 20 dermatopathology reference describes erythema dyschromicum perstans ashy dermatosis histopathology including histologic features and provides links to additional medical references. Erythema dyschromicum perstans edp is an uncommon, somewhat dubious cutaneous eruption of unknown etiology first described by ramirez in 1957.
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